Glucosamine, Chondroitin, and Hyaluronic Acid by Solaray, 1500mg/1000mg/20mg, 90 capsules


This advanced formula helps to maintain joint lubrication and promotes mobility, flexibility and full range of motion. This formula may also help to alleviate symptoms of osteoarthritis like pain, inflammation, and swelling.

Studies show that hyaluronic acid plays an important role in joint lubrication,1 has an analgesic effect in joints (thus reducing pain),2 and that people with rheumatoid arthritis have reduced levels of hyaluronic acid in their joints. 3 In addition, several studies have shown that intra-articular injection of hyaluronic acid can reduce many of the symptoms of osteoarthritis.4 While oral supplementation with hyaluronic acid is not the same as intra-articular injection, hyaluronic acid does have oral bioavailability,5 and many anecdotal reports support that oral supplementation with hyaluronic acid improves joint mobility and comfort in people with osteoarthritis.

Numerous studies also support that glucosamine supplementation may help to alleviate symptoms of osteoarthritis.6-9

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Full ingredient list: glucosamine (from shellfish), chondroitin sulfate (bovine), hyaluronic acid (microbial fermentation), vegetable cellulose (capsule), silica, and magnesium stearate.

90 capsules


  1. Swann DA, Radin EL, Nazimiec M, Weisser PA, Curran N, Lewinnek G. Role of hyaluronic acid in joint lubrication. Annals of the rheumatic diseases. 1974; 33(4):318-26. [pubmed]
  2. Gotoh S, Onaya J, Abe M, et al Effects of the molecular weight of hyaluronic acid and its action mechanisms on experimental joint pain in rats.
  3. Balazs EA, Watson D, Duff IF, Roseman S. Hyaluronic acid in synovial fluid. I. Molecular parameters of hyaluronic acid in normal and arthritis human fluids. Arthritis and rheumatism. 1967; 10(4):357-76. [pubmed]
  4. Wang CT, Lin J, Chang CJ, Lin YT, Hou SM. Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. A meta-analysis of randomized controlled trials. The Journal of bone and joint surgery. American volume. 2004; 86(3):538-45. [pubmed]
  5. JIANG Qiu-yan, LING Pei-xue, HUANG Si-ling, LIN Hong, ZHANG Tian-min. Study on absorption of hyaluronic acid after an oral administration in rats. Chinese Pharmaceutical Journal. 2005-23.
  6. McAlindon TE, LaValley MP, Gulin JP, Felson DT. Glucosamine and Chondroitin for Treatment of Osteoarthritis: A Systematic Quality Assessment and Meta-analysis. JAMA. 2000;283(11):1469–1475.
  7. Richy F, Bruyere O, Ethgen O, Cucherat M, Henrotin Y, Reginster JY. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Archives of internal medicine. 2003; 163(13):1514-22. [pubmed]
  8. Reginster JY, Deroisy R, Rovati LC, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet (London, England). 2001; 357(9252):251-6. [pubmed]
  9. Wolfgang Noack, Michael Fischer, Klaus K.Förster, Lucio C. Rovati, Ivo Setnikar. Glucosamine sulfate in osteoarthritis of the knee. Osteoarthritis and Cartilage. Volume 2, Issue 1, March 1994, Pages 51-59.


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